serum copper article

Excess of copper is eliminated in feces, both as absorbed and unabsorbed metal ions and from biliary excretion, averaging 0.5–1.3 mg per day, and with small amounts in urine, saliva and perspiration. The average intake of copper by human adults varies from 0.6 to 1.6 mg per day and the main sources are seeds, grains, nuts and beans, shellfish ...

Article. Published: 29 July 2022. Nutrition in acute and chronic diseases. Relationship of serum copper and zinc with kidney function and urinary albumin to creatinine ratio: …

Staging of Wilson Disease. Stage 1: initial accumulation of copper in the liver. Stage 2: Acute redistribution of copper within the liver, followed by release into the systemic circulation. Stage 3: Chronic accumulation of copper into extrahepatic tissues including brain. Stage 4: Use of chelation therapy to restore copper balance.

Volume 33, Issue 1, January 2024, 107473. Association between serum copper levels and stroke in the general population: A nationally representative study. Author links open …

Abstract. Background and Objective: Serum copper has been linked to the risk of atherosclerotic cardiovascular disease (CVD). However, the potential association between serum copper and venous thromboembolism (VTE) is not known. The principal aim was to evaluate the potential prospective association between serum copper and …

As shown in Table 1 and Figure 1, 722 subjects aged 18-years or older were included in this study.For exposures of interest, serum copper concentrations (108 vs. 130 μg/dL) were significantly lower in men than in women. For outcomes of interest, BMD in total femur (1.00 vs. 0.91 g/cm 2), femoral neck (0.81 vs. 0.76 g/cm 2) and total spine …

Then, 42 articles were excluded because of not being the serum sample (9 in whole blood, 6 in plasma, 13 in toenail or hair, and 14 in tissue). Further, 11 articles (4 with duplicated data, 5 lacked of available data, and 2 with abnormal high levels of Zn) were excluded. Finally, a total of 36 studies available. serum copper and breast cancer

Moderate to severe copper deficiency is typified by decrements in serum copper and CP activity ( 6 ). CP carries most circulating copper; thus, changes in blood copper likely reflect changes in CP concentrations. Using serum Cu and CP activity as bioindicators of copper status is, however, complicated because infection and …

Abstract. Serum copper and thiol levels an caeruloplasmin activity were determined and compared with measurements of articular index, erythrocyte sedimentation rate, and zinc and haemoglobin levels in patients with rheumatoid arthritis. Superoxide dismutase activity, thiol, zinc, and copper levels of haemolysate were measured and compared with ...

Objective: To compare the serum levels of copper (Cu), zinc (Zn), selenium (Se) and copper/zinc ratio in women with unexplained infertility and fertile women. Subjects and methods: This was a cross-sectional analytical study that compared 75 consenting women who had unexplained infertility with 74 fertile women that were controls. Both groups ...

Eleven studies suggested that serum copper levels are higher in patients with cervical cancer compared with that in controls, while one article had reported the lack of significant association. However, two publications [ 20, 21 ] indicated that it was significantly lower in patients with cervical cancer relative to controls about serum copper ...

Among the levels of serum copper, selenium, and zinc, only the association between depression symptoms and serum copper levels was observed to be significant in the unadjusted model (P = 0.002). Individuals with a high copper level (114–134 μg/dL) and a very high copper level (≥ 134 μg/dL) had 1.85 (95% CI 1.24, 2.77)- and 1.72 (95% CI 1. ...

Abstract. Trace elements play a critical role in the pathogenesis of autism spectrum disorders (ASD). The aim of this study was to investigate the serum levels of zinc (Zn) and copper (Cu) in Chinese children with ASD. Sixty patients (48 males, 12 females) diagnosed with ASD and 60 healthy -matched and age-matched control participants …

Serum iron was measured by ferrozine method, magnesium by magnesium-calmagite method, zinc was measured using zinc reaction with nitro-PAPS and copper reaction with Di-Br-PAESA using the spectrophotometer. [10, 11] Samples were treated with 1% fresh hypochlorite solution for 30 min before they were discarded. Means were used …

The aims of this study were to investigate the association between S-Cu and risk of major adverse cardiovascular events (MACE), including total stroke, ischemic stroke, hemorrhagic stroke, myocardial infarction and cardiovascular …

Recently, Luo found that serum copper level was inversely linked with BMI-corrected handgrip strength, and the beta coefficients (95% confidence intervals) comparing the fourth to the lowest quartiles of serum Cu concentration was − 0.36 kg (− 0.44; − 0.28); and a non-linear association was detected between them, also in line with our ...

Serum Cu to Zn ratio modulates immune defense, growth stimuli and stress response. •. Cu to Zn changes with aging might reflect the attempt of the body to repair itself. The serum concentrations of copper (Cu) and zinc (Zn) are strictly regulated by compensatory mechanisms that act to stabilize them within certain ranges of nutritional …

Dysregulation in total body copper causes severe complications and excess copper can be toxic. Divalent metal transporter 1, duodenal cytochrome B, and copper transporter ATPase7A are included in the many intestinal genes transactivated by HlF-α. On July X, 2022 an 80-year-old patient on peritoneal dialysis was prescribed …

Background Copper (Cu) homeostasis and Cu-induced cell death are gaining recognition as crucial processes in the pathogenesis of cardiovascular disease (CVD). Circulating Cu associated with CVD and mortality is yet to be fully elucidated. Objective This national prospective cohort study is to estimate relationship between serum Cu and the …

Serum ceruloplasmin is also a valuable test and can be used to determine the free serum copper. Copper reference ranges are as follows: Free serum copper: 1.6-2.4 μmol/L or …

Background: Several studies have shown that serum copper levels are related to coronary heart disease, diabetes, and cancer. However, the association of serum copper levels with all-cause, causespecific (including cardiovascular disease [CVD] and cancer) mortality remains unclear.Objectives: This study aimed to prospectively examine …

The role of serum copper as a putative risk factor for CVDs requires further exploration. The exact mechanisms underlying the association between elevated serum copper …

This article was performed through using Preferred Reporting Items about Systematic Reviews and Meta-Analyses guidelines to select relevant studies between serum copper and ischemic stroke (Beller et al. 2013). Search terms were the following: "trace elements" or "copper" or "Cu" and "cerebrovascular disease" or "stroke" or ...

Copper is an essential element required for normal human metabolism. Studies indicated that serum Copper deficiency in pregnant women can have been associated with some adverse effects such as Premature Rupture of Membrane (PROM), abortion, fetus growth restriction etc . Zinc (Zn) is essential for cell growth, development …

There are conflicting reports on the correlation between serum levels of selenium (Se), copper (Cu), and magnesium (Mg) with thyroid cancer. The purpose of the present study is to clarify the association between Se, Cu, and Mg levels with thyroid cancer using a meta-analysis approach. We searched articles indexed in PubMed published as …

The serum copper distribution was depicted using the histogram. Adjusted hazard ratios (95% CI) for CVD and all-cause mortality are shown with red curves. The serum copper level considered for this analysis was 18.1 µmol/L. The model cubic spline curves have 3 knots. Adjustments included age, , marital, education, BMI, eGFR, …

Excessive serum copper has multiple effects on human health, while the association between copper and obesity remains unclear. The objective of this study is to examine the associations of serum copper concentrations with obesity and adiposity measures, including body fat composition and distribution among adults in the USA. This …

ORIGINAL ARTICLE. Open Access. The association between serum copper concentration and prevalence of diabetes among US adults with hypertension (NHANES …

High serum copper might be related to the development of the pathological lesions observed in RA and not just be a secondary response. Full text Get a printable copy (PDF file) of the complete article (536K), or click on a page image below to browse page by page.

Purpose Serum copper (Cu), zinc (Zn), and Cu/Zn-ratio have emerged as ageing-related biomarkers. We sought to assess the association between Cu/Zn-ratio and chronic obstructive pulmonary disease (COPD) risk. Methods Serum Cu and Zn were measured using atomic absorption spectrometry in 2,503 men aged 42–61 years. …

The serum copper concentration was quantified using inductively coupled plasma dynamic reaction cell mass spectrometry (ICP-DRC-MS), a powerful multielement analytical technique with the ability to detect even trace levels of elements. All the data exceeded the lower limit of detection (LLOD) for the tests. The LLOD of serum copper …